ATP stimulation of Na1/Ca21 exchange in cardiac sarcolemmal vesicles
نویسندگان
چکیده
GRACIELA BERBERIÁN,1 CECILIA HIDALGO,2 REINALDO DIPOLO,3 AND LUIS BEAUGÉ1 1Instituto de Investigación Médica Mercedes y Martı́n Ferreyra, 5000 Córdoba, Argentina; 2Centro de Estudios Cientı́ficos de Santiago, Santiago 9; and Departamento de Fisiologı́a y Biofı́sica, Facultad de Medicina, Universidad de Chile, Santiago 7, Chile; and 3Laboratorio de Permeabilidad Iónica, Instituto Venezolano de Investigaciones Cientı́ficas, Caracas 1020-A, Venezuela
منابع مشابه
Cardiac expression of the Na1/Ca21 exchanger NCX1 is GATA factor dependent
Nicholas, Susanne B., and Kenneth D. Philipson. Cardiac expression of the Na1/Ca21 exchanger NCX1 is GATA factor dependent. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H324–H330, 1999.—The cardiac sarcolemmal Na1/Ca21 exchanger plays a primary role in Ca21 efflux and is important in regulating intracellular Ca21 and beat-to-beat contractility. Of the three Na1/Ca21 exchanger genes cloned (NC...
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The Na+-Ca2+ exchange activity of purified canine cardiac sarcolemmal vesicles can be strikingly stimulated if the vesicles are pretreated with a serine or thiol proteinase. The Km (Ca2+) for Na+i-dependent Ca2+ influx is reduced from 22.2 +/- 2.3 to 8.1 +/- 0.3 microM while Vmax is increased from 15.1 +/- 3.6 to 18.9 +/- 5.2 nmol Ca2+ . mg protein-1 . s-1. Na+o-dependent Ca2+ efflux is also st...
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We have measured Na+-CaZ+ exchange in the insideout vesicles of highly purified cardiac sarcolemma from dog ventricles. This was accomplished in a mixed population of Sarcolemmal vesicles by first loading the inside-out vesicles with Na+ through the action of the glycoside-sensitive, ATP-dependent Na' pump. Due to the asymmetric nature of active Na' transport, this will only occur in inside-out...
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